Human papillomavirus-associated cancers: A growing global problem
نویسندگان
چکیده
منابع مشابه
Genomic landscape of human papillomavirus-associated cancers.
Recent next-generation sequencing studies have generated a comprehensive overview of the genomic landscape of human papillomavirus (HPV)-associated cancers. This review summarizes these findings to provide insight into the tumor biology of these cancers and potential therapeutic opportunities for HPV-driven malignancies. In addition to the tumorigenic properties of the HPV oncoproteins, integra...
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Approximately 15-20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways that control recognition by the immune system, proliferation, differentiation, genomic integrity, and cell death. Given that key proteins in these...
متن کاملRisk of human papillomavirus-associated cancers among persons with AIDS.
BACKGROUND Although risk of human papillomavirus (HPV)-associated cancers of the anus, cervix, oropharynx, penis, vagina, and vulva is increased among persons with AIDS, the etiologic role of immunosuppression is unclear and incidence trends for these cancers over time, particularly after the introduction of highly active antiretroviral therapy in 1996, are not well described. METHODS Data on...
متن کاملGender Bias in Human Papillomavirus-Associated Anal and Oral Cancers
HPV-associated anal and oral cancers are increasing. The reason is still unclear although sexual behavior changes in the general population are postulated as one of the factors. The incidence is drastically higher in specific risk groups, such as men who have sex with men, and HIV-1 infected individuals. Interestingly, anal cancer is predominant in women while a higher incidence of oral cancer ...
متن کاملTherapeutic startegies for human papillomavirus infection and associated cancers.
Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages wher...
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ژورنال
عنوان ژورنال: International Journal of Applied and Basic Medical Research
سال: 2016
ISSN: 2229-516X
DOI: 10.4103/2229-516x.179027